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KMID : 0352719930170020109
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Journal of Ginseng Research
1993 Volume.17 No. 2 p.109 ~ p.113
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Effects of Ginseng Total Saponins sand U-50,488H on Electrically Induced Twitch Responses of Mouse Vas Deferens
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김학성
성연희/김선혜/김석창/최강주/오기완
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Abstract
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The effects of ginseng total saponins (GTS) on the action of U-50,488H, a k-opioid receptor agonist, on the electrically induced twitch responses of mouse vas deferens were studied. U-50,488H (10E-9~10-5 M) inhibited the twitch contractions in a
dose-dependent manner, which were caused by adenosine 5-triphosphate (ATP) released from the stimulated sympathetic nerve, and this effect was antagonized by naloxone (10-6M). GTS. Which itself induced the inhibition of the twitch contractions,
acted
additively to U-50,488, GTS and U-50,488H had no effect on the tension of the unstimulated organs. The contractions elicited by ATP were not affected by U-50,488H, but inhibited by GTS. These results suggest that U-50,488H suppressed the twitch
contractions by the inhibition of neurotransmitter release from presynaptic nerve terminals via action on opioid receptor, but GTS, by inhibiting the action of the neurotransmitter on the smooth muscle.
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